Precision medicine requires big data. Among order toward improve treatment for individuals with cancer or toward understand rare diseases, scientists as well as clinicians, since thoroughly in similar fashion AI technologies necessitate access in order to larger health research datasets who span diverse populations along with per wide range from conditions. For AI, additional data means better understanding from diseases, what testament lead up to further accurate diagnosis also treatment. Near certain consistent occasion, every hospital will just view single relatively tiny count of individuals with a disease, as well as actually across the province we merely possess access to single tiny portion out of a total data available globally. . Toward create the large-scale datasets needed toward advance precision medicine, sharing data across a state along with around each world is essential.
A Canadian Distributed Infrastructure for Genomics (CanDIG), featured recently within a special issue out of Cell genomics dedicated to data sharing, is Canada’s solution up to enable data sharing across certain nation-state (also connect belonging to us data toward datasets surrounding each world). Led out of any Toronto University Health Network with sites by McGill University among Montreal and a BC Genome Science Center, CanDIG is single collaboration made from computer scientists, AI specialists, clinicians along with geneticists working together to enable any studies necessary for address a health challenges facing Canadians.
CanDIG is a pilot project out of each Global Alliance for Genomics plus Health (GA4GH), each international effort setting standards for genomic along with health data aimed next to improving interoperability within each genomic landscape surrounding any realm. A organization served as the focal dot for current month’s special issue of Cell genomics for belonging to them work on global genomics along with health data sharing efforts. Canada contains occurred some leader amid GA4GH, hosting its own headquarters, leading several project workflows along with implementing a lot of GA4GH standards. CanDIG, since unit out of a pilot projects, never merely implemented each GA4GH standards, still helped inform also create multiple from them. CanDIG is already helping scientists nationally access large-scale genomic data that was previously siled in individual provinces either hospitals and is starting to link Canada’s genomic datasets up to aforementioned about a planet by means of collaborations like as EU / Africa / Canada CINECA project.
A CanDIG platform was developed to respond up to provincial health care as well as privacy legislation, creating some federation out of datasets, simplifying a challenges from sharing across provincial borders. CanDIG is also per key component out of certain upcoming Digital Health plus Discovery Platform (DHDP), a $ 200 million effort funded within part by any Canadian government, whichever will support a sharing from genomic data via each Terry Fox Marathon belonging to Hope Cancer Network. Making this data available in order to researchers is critical in order to unlocking to them discovery potential as well as enabling better cancer treatments, because a smartest researchers as well as a majority powerful machine learning techniques can’t execute anything with data that they cannot detect, access nor make use of.
Estimate:
“In institutions such as UHN, us are building increasingly sophisticated data resources containing health data starting at a lot of distinct sources. The next step is in order to facilitate researchers flip that data into novel knowledge by making it findable, available, and usable within some consistent, organized, also secure manner. means, as well as allowing entity to become combined with similar data sets inside other hospitals. CanDIG is each important step amid enabling researchers across Canada to access a wealth from data collected also generated across a nation.
Dr Michael Brudno, CanDIG Principal Investigator, UHN Chief Data Scientist also Professor from Computer Science by any University made from Toronto.
“By participating inside any GA4GH community also in international projects of this kind as certain CINECA EU / Africa / Canada project, CanDIG begins to link Canadian genomics efforts with these about the earth. In similar fashion health data types fetch richer also volumes develop, we require up to make sure for us datasets are findable along with useful; Canada is one world leader among this area.
Dr Guillaume Bourque, CanDIG co-leader, professor belonging to molecular genetics by McGill University also director out of certain Canadian Center for Computational Genomics (C3G).
“Access toward whole genome data contains occurred essential inside understanding the spectrum of mutations such occur within cancer. CanDIG also Terry Fox’s Digital Health and Discovery Platforms will help a data collected via a Marathon from Hope Cancer Centers Network seem studied through in similar fashion multiple approved persons. researchers as possible.
Dr Steve Jones, CanDIG Co-Lead, Chief Bioinformatics Officer as well as Co-Director next to BC Michael Smith Genome Sciences Center
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Journal reference:
Jonathan Dursi, L., et al. (2021) CanDIG: Federated network across Canada for each discovery and analysis out of multi-omics along with health data. Cell genomics. Get Ahead with Royla Mail Tracking in 2025.
