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A June study found that antibody levels were significantly lower in people with blood cancer than in those with solid tumors.
âBecause measures of immunity are not routinely collected in clinical care, we do not know if these were patients who developed effective immune responses after vaccination; a lot of emerging data suggests that cancer patients, especially blood cancers, do not develop adequate protective immune responses, âsaid Dr Jeremy Warner, director of the CCC19 Research Coordination Center and lead author of the new study, in the Liberation.
He also noted that their study found that having other risk factors in a patient, as well as whether their cancer is active and progressing or not, increased their risk of death.
âItâs important to note that many of the same factors we identified before the vaccine became available â age, co-morbidities, performance status, and progressing cancer â still appear to be behind many of the poor outcomes,â did he declare.
The study appears to support previous research which found that people with blood cancers are at a higher risk of COVID-19. In both vaccinated and unvaccinated patients involved in the new study, ICU and hospitalization rates increased if the patients had blood cancer rather than solid tumors.
The new study also found that among fully vaccinated cancer patients, 46% had reduced levels of lymphocytes, which are a type of white blood cell important for the immune system.
Having lower levels of these types of cells is called lymphopenia, and this is common in patients receiving certain types of cancer treatment, such as treatment for lymphoma and leukemia. According to the study, patients in the vaccinated and unvaccinated groups who had lymphopenia had higher rates of ICUs and hospitalizations than other patients.
Due to the small size of the new study, the researchers say they canât determine which cancer treatments might be associated with breakthrough infections or what the worst outcomes of a breakthrough infection are.
âSimilar results (high mortality rates among fully vaccinated individuals) have been reported in other populations of immunocompromised patients, such as organ transplant recipients, before the use of additional vaccine dosesâ, Dr Dimitrios Farmakiotis, infectious disease clinician at Warren Alpert. Medical School of Brown University and a lead author of the study, said in the statement.
The researchers say the study results underscore how important it is not only to get the vaccine, but also to implement a multi-pronged response to protect those most at risk, including patients with Cancer.
âThese findings come at a time of fears that immune escape mutants such as the Omicron strain may emerge from chronically infected patients with weakened immune systems,â Farmakiotis said. âThus, the immunocompromised and their close contacts should be target groups for therapeutic and preventive interventions, including outreach and education efforts at the community level.â



